Wisconsin Viral Research Group, Ltd. Donald R. Carrigan, Ph.D.

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Donald R. Carrigan, Ph.D.

Vice President and Director of Clinical Laboratory
Wisconsin Viral Research Group, Ltd.
10437 Innovation Drive, Suite 321
Milwaukee, Wisconsin 53226
Telephone: (414) 774-8612
Fax: (414) 453-7295

Curriculum Vitae

Education

California Institute of Technology, 1970-1974
Pasadena, California
B.S. Biology

University of California, San Francisco, 1976-1979
San Francisco, California
Ph.D. Experimental Pathology

Department of Neurology, 1979-1981
University of California, San Francisco
San Francisco, California
Post Doctoral Fellowship
Neurovirology; Dr. Richard Barringer (mentor)

Professional Appointments

Assistant Research Virologist, 1981
Department of Neurology
University of California, San Francisco
San Francisco, California

Research Assistant Professor, 1981-1987
Department of Neurology
University of Maryland at Baltimore
Baltimore, Maryland

Adjunct Research Assistant Professor, 1981-1987
Department of Microbiology
University of Maryland at Baltimore
Baltimore, Maryland

Assistant Professor, 1987-1991
Department of Pathology
Medical College of Wisconsin
Milwaukee, Wisconsin
Associate Professor, 1991-1996
Department of Pathology
Medical College of Wisconsin
Milwaukee, Wisconsin

Director, Diagnostic Virology Laboratory, 1987-1996
Milwaukee Regional Medical Center
Milwaukee, Wisconsin

Director, Serology Laboratory, 1991-1994
Milwaukee County Medical Complex
Milwaukee, Wisconsin

Director, Molecular Diagnostics Laboratory, 1991-19933
Department of Pathology
Medical College of Wisconsin
Milwaukee, Wisconsin

Clinical Associate Professor, 1994-1998
Division of Clinical Laboratory Sciences
University of Wisconsin
Milwaukee, Wisconsin

Memberships in Professional Societies

American Society for Microbiology
American Association for the Advancement of Science
International Society for Antiviral Research
International AIDS Society

Teaching Experience

Lecturer; Sophomore Microbiology Course, 1981-1987
Medical Microbiology (MMIC 520)
University of Maryland School of Medicine
Baltimore, Maryland

Instructor, Freshman Neuroscience Course, 1981-1987
Neuroscience I
University of Maryland School of Medicine
Baltimore, Maryland

Course Master, Graduate Course in Virology, 1981-1987
Advanced Animal Virology (MMIC 801)
University of Maryland School of Medicine
Baltimore, Maryland

Instructor, Sophomore Microbiology Course, 1987
Medical College of Wisconsin
Milwaukee, Wisconsin

Instructor, Advanced Virology Course, 1987
Department of Microbiology
Medical College of Wisconsin
Milwaukee, Wisconsin

Mentor Infectious Disease Fellows (3) 1988-1990
Department of Medicine
Medical College of Wisconsin
Milwaukee, Wisconsin

Specialized Clinical Virology Experience

Member Bone Marrow Transplantation Unit 1987-1996
Milwaukee County Medical Complex
Milwaukee, Wisconsin

Member Heart Transplantation Unit 1988-1996
Milwaukee County Medical Complex
Milwaukee, Wisconsin

Member Pediatric Heart-Lung Transplantation Unit 1990-1996
Children's Hospital of Wisconsin
Milwaukee, Wisconsin

Member Lung Transplantation Unit 1989-1996
Milwaukee County Medical Complex
Milwaukee, Wisconsin

Consultant Special Infectious Diseases (HIV/AIDS) Clinic 1988-1996
Milwaukee County Medical Complex
Milwaukee, Wisconsin

Graduate Student Responsibilities

Associate Member of the Graduate Faculty; University of Maryland at Baltimore; 1981-1987.

Member of the Graduate Student Admissions Committee; Department of Microbiology; University of Maryland School of Medicine; 1981-1987.
Member of the Graduate Faculty; Medical College of Wisconsin; 1987-1996

Research and Thesis Committees

Major Professor

Cyrus B. Toorkey, Ph.D.; August, 1989. Department of Pathology; Medical College of Wisconsin.

Eileen M. Burd, Ph.D.; June 1993. Department of Pathology; Medical College of Wisconsin.

Konstance Kehl Knox, Ph.D.; December 1994. Department of Pathology; Medical College of Wisconsin.

Member of Committee

Dominique Y. Pifat, Ph.D. January, 1985. Department of Microbiology; University of Maryland School of Medicine.

Peggy T. Swoveland, Ph.D. April, 1985. Department of Microbiology; University of Maryland School of Medicine.

Mary J. Geiger, Ph.D., May, 1990. Department of Pathology; Medical College of Wisconsin.

Nina K. Genthe, Ph.D., May, 1991. Department of Pathology; Medical College of Wisconsin.

Barry J. Browne, M.S. May, 1991. Department of Pathology; Medical College of Wisconsin.

Jeanette Bjerke, M.S., May, 1992. Department of Microbiology; Medical College of Wisconsin.

Julie Hammerling, M.S. December, 1994. Clinical Laboratory Sciences; University of Wisconsin, Milwaukee.

Lisa M. Hoffman, Ph.D. December, 1995. Department of Microbiology; Medical College of Wisconsin.

Administrative Committee Memberships

Dean's Safety Advisory Committee; University of Maryland School of Medicine, 1984.

Dean's Task Force on Teaching Methodologies; University of Maryland School of Medicine; 1985-1987.

AIDS Research Coordinating Committee; University of Maryland School of Medicine; 1986-1987.

Chairman, Pathogen Subcommittee; Laboratory Safety Committee, Medical College of Wisconsin; 1988-1992.

Institutional Animal Care and Use Committee (IACUC); Medical College of Wisconsin; 1988-1991.

Interdisciplinary Lecture Committee, Medical College of Wisconsin; 1989-1992. Member; Cancer Center of the Medical College of Wisconsin; 1987-1996.

Vice-Chairman, Institutional Review Board (IRB), Wisconsin Community Based Research Consortium (HIV/AIDS Research); Milwaukee, Wisconsin. 1991-1993.

Internal Research Review Committee; Cancer Center of the Medical College of Wisconsin; Milwaukee, Wisconsin. 1993-1996.

Consultant Positions

Biosafety Consultant; Pharmacia P-L Biochemicals;
Milwaukee, Wisconsin, 1988-1996

Special Reviewer:
AIDS Related Research Study Section 3
NIAID
National Institutes of Health
Bethesda, Maryland
February, 1993

Clinical Virology/Viral Diagnostic Testing
Pel-Freez Clinical Systems
Pel-Freez Inc.
Brown Dear, Wisconsin

Peer Reviewer for Journals and Funding Agencies

Proceedings of the National Academy of Sciences
Virology
Journal of Infectious Diseases
British Journal of Psychiatry
US Veterans Administration Merit Review
Clinical Microbiological Reviews
European Journal of Clinical Microbiology and Infectious Diseases
Immunology Today
Annals of Epidemiology
Blood
Journal of Virology
The Wellcome Trust; London, Great Britain
AIDS Research and Human Retroviruses
Journal of Neurovirology
Clinical Infectious Diseases

Patents

Title: Human Virus Associated with Chronic Fatigue Immune Deficiency Syndrome and Assay Therefore
Inventors: Grossberg SE, Kushnaryov VM, Cashdollar LW, Carrigan DR and Knox KK
Number: 5,827,750
Status: Granted on October 27, 1998

Title: Rapid Method for Diagnosis of Human Herpesvirus 6
Inventors: Knox KK and Carrigan DR
Number: 60/079,379
Filing Date: March 26, 1998
Status: Pending

Selected Invited Lectureships

"Cytomegalovirus Infections in Solid Organ Transplant Recipients"
Clinical Transplant Forum
Regional Organ Bank of Illinois
Rosemont, Illinois
March 9, 1995

"HHV-6 Infections in Immunocompromised Patients"
Session Chairman
International Conference on Human Herpesviruses 6 and 7
Atlanta, Georgia
April 9, 1995

"Ebola Virus Outbreak in Zaire"
On Air Interview and Call-in Talk Show
WHAD, Wisconsin Public Radio
Milwaukee, Wisconsin
May 12, 1995

"Ebola Hemorrhagic Fever"
On Air Interview
Morning Magazine, WBKV Radio
West Bend, Wisconsin
May 28, 1995

"Pathogenesis and Diagnosis of Human Herpesvirus Six (HHV-6) Infections in Immunocompromised Patients"
Pediatric Grand Rounds
Memorial Sloan-Kettering Cancer Center
New York, New York
September 14, 1995

"Human Herpesvirus Six and Demyelinating Diseases of the Central Nervous System"
1996 Annual Meeting of the Institute of Human Virology
University of Maryland Biotechnology Institute
University of Maryland at Baltimore
Baltimore, Maryland
September 8, 1996

"Pathology and Laboratory Diagnosis"
Community Respiratory Viral Disease in the Immunocompromised Host
Investigators Meeting
36th Interscience Conference on Antimicrobial Agents and Chemotherapy
New Orleans, Louisiana
September 15, 1996

"Adenovirus: Community Acquired?"
Community Respiratory Viral Disease in the Immunocompromised Host
Investigators Meeting
36th Interscience Conference on Antimicrobial Agents and Chemotherapy
New Orleans, Louisiana
September 15, 1996

"Human Herpesvirus Six: Roles in AIDS and Central Nervous System Disease"
Abbott Laboratories
Pharmaceutical Products Division
100 Abbott Park Road
Abbott Park, Illinois 60064-3500
October 30, 1996

"Human Herpesvirus Six: Roles in AIDS and Central Nervous System Disease"
Special Seminar
Institute of Human Virology
University of Maryland Biotechnology Institute
University of Maryland at Baltimore
725 W. Lombard Street
Baltimore, Maryland 21201
November 7, 1996

"Role of Human Herpesvirus Six in Multiple Sclerosis"
Annual Meeting of the American Neurological Association
San Diego, California
September 28, 1997

"HHV 6, 7 and 8 in Non-HIV Infected Immunocompromised Patients"
Conference on Emerging Viral Infections in the Immunocompromised Host
Sponsored by University of Texas M.D. Anderson Cancer Center
Laguna Niguel, California
November 16-18, 1997

Past and Current Research Support

Coinvestigator
Project Title: Biology of Latent Measles Infection of the CNS
NIH Grant Number: R01 NS18172-02
Period of Support: 7/01/81-12/31/83
Annual Direct Costs: $71,371

Principal Investigator
Project Title: Molecular Pathogenesis of Measles Infection in the CNS
Annual Direct Costs: $82,455
Subproject in:
ALS and MS Clinical Center Grant
Principal Investigator: Kenneth P. Johnson, M.D.
Period of Support: 12/01/83-11/30/86
Annual Direct Cost: $404,754

Principal Investigator
Project Title: Immunohistochemical Analysis of Interferon Production in
Acute and Chronic Viral Infections of the CNS
Chancellor's Special Research Initiative Support; University of Maryland
School of Medicine
Period of Support: 1/14/87-7/1/87
Amount of Support: $5,000

Principal Investigator
Project Title: Pathogenic Mechanisms of Measles Infection of the CNS
R01 NS 24665; NINCDS, NIH
Period of Support: 9/1/87-8/31/90
Annual Direct Cost: $96,097 (first year)

Principal Investigator
Project Title: Role of Cytomegalovirus in Atherosclerosis
American Heart Association
Period of Support: 7/1/90-6/30/91
Annual Direct Cost: $29,600

Co-Principal Investigator
Project Title: Structural and Biologic Characterization of JHK Virus
Cancer Center of the Medical College of Wisconsin
Period of Support: 7/1/90-6/30/91
Annual Direct Cost: $10,000

Co-Principal Investigator
Project Title: Structural and Biologic Characterization of JHK Virus
American Cancer Society
Period of Support: 9/1/90-8/31/91
Annual Direct Cost: $75,000

Principal Investigator
Project Title: Pathogenicity of HHV-6 in Marrow Transplantation
American Cancer Society Grant Number EDT-19
Period of Support: 7/1/92-6/30/95
Annual Direct Cost: $104,000

Principal Investigator
Project Title: HHV-6 in Multiple Sclerosis
Pilot Research Grant
National MS Society
Period of Support: 3/1/97-2/28/98
Annual Direct Cost: $25,000

Co-Principal Investigator
Project Title: Role of HHV-6A in the Chronic Fatigue Syndrome
Research Grant
The CFIDS Association of America, Inc.
Period of Support: June 1, 1997 through May 31, 1998
Annual Direct Cost: $84,500

Co-Principal Investigator
Project Title: Prospective Study of HHV-6 Infections in Liver Transplant Recipients
Thomas E. Starzl Transplantation Institute
Period of Support: January 1, 1998 through June 30, 1998
Annual Direct Cost: $20,000

Co-Principal Investigator
Project Title: Prospective Study of HHV-6 in Multiple Sclerosis
Research Grant
National MS Society
Period of Support: 6/1/98-5/30/99
Annual Direct Cost: $25,000

Co-Principal Investigator
Project Title: Ganciclovir Treatment of Patients with Multiple
Sclerosis: Evaluation of Drug Toxicity and Suppression of Human Herpesvirus Six Viremia
Roche Laboratories
Period of Support: September 1, 1999 through August 31, 2000
Annual Direct Cost: $80,000

Co-Principal Investigator
Project Title: In Vitro Screening of Compounds for Ability to Suppress the Replication of Human Herpesvirus Six: Special Reference to Chronic Fatigue Syndrome
The CFIDS Association of America
Period of Support: 4/1/99 - 3/31/00
Annual Direct Cost: $29,500

Selected Publications (from total of 74):

Papers

1. Knox KK, Pietryga D, Franciosi R, and Carrigan DR. (1995). Progressive immunodeficiency and fatal pneumonitis associated with HHV-6 infection in an infant. Clin Infect Dis, 20:406-413.

2. Secchiero P, Carrigan DR, Benedetti L, Crowley RW, Komaroff AL, Gallo RC, and Lusso P. (1995). Detection of HHV-6 in serum of immunosuppressed individuals by polymerase chain reaction. J Infect Dis, 171:273-280.

3. Carrigan DR. (1995). Human herpesvirus six (HHV-6) and bone marrow transplantation. Blood, 85:294-295.

4. Knox KK, Carrigan DR. (1995). Active human herpesvirus six (HHV-6) infection of the central nervous system in patients with AIDS. J Immune Defic Syndr and Hum Retrovir 9:69-73.

5. Knox KK, Harrington D and Carrigan DR. (1995). Fulminant human herpesvirus six (HHV-6) encephalitis in an HIV infected infant. J Med Virol, 45:288-292.

6. Flomenberg P, Balliet K, Bernstein B, Gutierrez E, and Carrigan DR. (1995). High specificity of hepatitis C second generation enzyme immunoassay in HIV infected patients. J Acquired Immune Defic Syndr and Hum Retrovirol 9:97-98.

7. Carrigan DR and Knox KK. (1995). Bone marrow suppression by human herpesvirus six (HHV-6): Comparison of the A and B variants of the virus. Blood, 86:835-836.

8. Rosenfeld CS, Weinbaum D, Carrigan DR, Knox KK, Andrews DF, and Shadduck RK. (1995). Late graft failure due to dual bone marrow infection with variants A and B of human herpesvirus 6. Exper Hematol, 23:626-629.

9. MacKenzie I, Carrigan DR, and Wiley CA. (1995). Chronic myelopathy associated with human herpesvirus six. Neurology, 45:2015-2017.

10. Singh N, Gayowski T, Carrigan DR, and Singh J. (1995). Human herpesvirus 6 associated febrile dermatosis with thrombocytopenia and encephalopathy in a liver transplant recipient. Transplantation, 60:1355-1357.

11. Knox KK and Carrigan DR. (1996). Chronic marrow suppression in a bone marrow transplant patient associated with persistent HHV-6 marrow infection. Clin Infect Dis, 22:174-175.

12. Knox KK and Carrigan DR. (1996). Active HHV-6 infection in the lymph nodes of HIV infected patients: In vitro evidence that HHV-6 can break HIV latency. J Acquired Immune Defic Syndr and Hum Retrovirol, 11:370-378.

13. Singh N and Carrigan DR. (1996). Human herpesvirus six in transplantation: An emerging pathogen. Ann Intern Med, 124:1065-1071.

14. Carrigan DR, Harrington D and Knox KK. (1996). Subacute leukoencephalitis caused by CNS infection with human herpesvirus six manifesting as acute multiple sclerosis. Neurology, 47:145-148.

15. Carrigan DR, Harrington D and Knox KK. (1996). Variant A human herpesvirus six as a cofactor in the pathogenesis of AIDS. J Acquired Immune Defic Syndr and Hum Retrovirol, 13:97-98.

16. Hammerling JA, Lambrecht RS, Kehl KS and Carrigan DR. (1996). Prevalence of HHV-6 in autopsy derived lung tissue of pediatric patients with pneumonitis. J Clin Pathol, 49:802-804.

17. Carrigan DR. (1997). Adenovirus as a community acquired respiratory viral disease in the immunocompromised host. Amer J Med, 102:71-74.
18. Singh N, Gayowski T and Carrigan DR. (1997). Human herpesvirus six (HHV-6) infection in liver transplant recipients: Documentation of pathogenicity. Transplantation 64, 674-678.

19. Paterson D, Singh N and Carrigan DR. (1999). Human herpesvirus six encephalitis liver transplantation. Liver Transplant Surgery, 5:454-455.

20. Carrigan DR and Knox KK. (1999). Pathogenic role of human herpesvirus 6 in transplantation. Curr Opin Organ Transplant, 4:285-291.

21. Rogers J, Singh N, Carrigan DR, Rohal S, Kusne S, Knox KK, Wagener MM and Fung JJ. (2000). Prospective study of direct and indirect sequelae of human herpesvirus 6 infection in liver transplant recipients. Transplantation, in press.

22. Knox KK, Brewer JH, Harrington DJ, Henry JM, and Carrigan DR. (2000). Active infection of CNS tissues, peripheral blood leukocytes and lymphoid tissues with human herpesvirus six in patients with multiple sclerosis. Ann Neurol, submitted for publication.

Abstracts (partial listing)

1. Carrigan DR and Knox KK. Active human herpesvirus six (HHV-6) infection of the CNS in patients with AIDS. Second National Conference on Human Retroviruses and Related Infections, 1995, Washington, D.C.

2. Knox KK and Carrigan DR. In vitro studies of HHV-6 and HIV on low density bone marrow mononuclear cells. International Conference on Human Herpesviruses 6 and 7, 1995; Atlanta, Georgia.

3. Knox KK and Carrigan DR. Frequent HHV-6 infection of the bone marrows of patients with AIDS: Evidence for TNF-a induction and enhancement of HIV replication. 20th International Herpesvirus Workshop, 1995.

4. Carrigan DR, Milburn G, Knox K, Kernan N, Papadopoulos E, and Singh N. Diagnosis of active human herpesvirus six (HHV-6) infections in immunocompromised patients with a rapid shell-vial assay. Amer Soc Microbiol, 1996.

5. Knox KK and Carrigan DR. Human herpesvirus six and demyelinating diseases of the central nervous system. 1996 Institute of Human Virology Annual Meeting. University of Maryland Biotechnology Institute. Baltimore, Maryland. September, 1996.

6. Knox KK and Carrigan DR. Histopathological correlates of HHV-6 infections in the lymph nodes of HIV-1 infected individuals. 1996 Institute of Human Virology Annual Meeting. University of Maryland Biotechnology Institute. Baltimore, Maryland. September, 1996.

7. Singh N and Carrigan DR. Human herpesvirus six (HHV-6) infection in liver transplant recipients: Documentation of pathogenicity. 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1996.

8. Knox KK, Harrington D and Carrigan DR. Variable Sensitivities of Human Herpesvirus Six Strains to Inhibition by Acyclovir. Second International Conference on Human Herpesviruses 6, 7 and 8. Pisa, Italy. May, 1997.

9. Knox KK, Harrington D and Carrigan DR. Human Herpesvirus Six and Demyelinating Diseases of the Central Nervous System. Second International Conference on Human Herpesviruses 6, 7 and 8. Pisa, Italy. May, 1997.

10. Knox KK and Carrigan DR. Histopathological Correlates of HHV-6A Infections in the Lymph Nodes of HIV-1 Infected Individuals. Second International Conference on Human Herpesviruses 6, 7 and 8. Pisa, Italy. May, 1997.

11. Knox KK and Carrigan DR. Active HHV-6 Infections in Patients with Chronic Fatigue Syndrome. Second International Conference on Human Herpesviruses 6, 7 and 8. Pisa, Italy. May, 1997.

12. Knox KK and Carrigan DR. Human Herpesvirus Six Associated Diseases of the Central Nervous System. 37th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1997.

13. Knox KK, Brewer JH, Harrington D and Carrigan DR. Active Human Herpesvirus Six Infections Are Present in the CNS, Lymphoid Tissues and Peripheral Blood of Patients with Multiple Sclerosis. 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1998.

14. Knox KK, Brewer JH and Carrigan DR. Multiple Sclerosis (MS) Patients Have Active Human Herpesvirus Six (HHV-6) Infections in their CNS, Lymphoid Tissues and Peripheral Blood. Annual Meeting of Infectious Disease Society of America, 1998.

15. KK Knox, JH Brewer and DR Carrigan. Persistent Active Human Herpesvirus Six Infections in Patients with Chronic Fatigue Syndrome. Fourth International American Association for Chronic Fatigue Syndrome Conference, 1998

16. Rogers J, Rohal S, Kusne S, Knox KK, Carrigan DR, Wagener MM, Fung JJ and Singh N. Human Herpesvirus 6 (HHV-6) Viremia is an Independent Predictor of Invasive Fungal Infections in Liver Transplant Recipients. 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1999.

17. Belko J, Burchett S, Knox KK and Carrigan DR. Fulminant Hepatitis in an Immunocompetent Child Associated with Active HHV-6 Variant A (HHV-6A) Infection. Satellite Workshop on Human Herpesviruses 6 and 7; 24th International Herpesvirus Workshop. Boston, Massachusetts. July, 1999.

18. Brewer JH, Knox and Carrigan DR. Human Herpesvirus Six (HHV-6) and Multiple Sclerosis: Active Infections are Preferently Present in the Blood of Patients with Early Disease. 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1999.

19. Knox KK and Carrigan DR. Human Herpesvirus Six (HHV-6) and Multiple Sclerosis: Potential Role as Trigger of the Disease Process. New York Academy of Sciences; New York, New York. October, 1999.

20. Brewer JH, Knox KK and Carrigan DR. Longitudinal Study of Chronic Active Human Herpesvirus 6 (HHV-6) Viremia in Patients with Chronic Fatigue Syndrome. 37th Annual Meeting of the Infectious Diseases Society of America, 1999.

21. Brewer JH, Knox KK and Carrigan DR. Severe Dysfunction of Natural Killer (NK) Cells Associated with Chronic Active Human Herpesvirus 6 (HHV-6) Viremia in Patients with Chronic Fatigue Syndrome. 37th Annual Meeting of the Infectious Diseases Society of America, 1999.

22. Achilleos AN, Lister J, Zeigler Z, Raymond JM, Knox KK, Carrigan DR, and Shadduck RK. Human Herpesvirus 6 (HHV-6) Infection After Hematopoietic Stem Cell Transplantation (HSCT). 41st Annual Meeting of the American Society of Hematology, 1999.

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