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Wisconsin Viral Research Group, Ltd.
Konstance K. Knox, Ph.D.
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Konstance K. Knox, Ph.D.
President and Director of Research
Wisconsin Viral Research Group, Ltd
10437 Innovation Drive, Suite 321
Milwaukee, Wisconsin 53226
Telephone: (414) 774-8612
Fax: (414) 453-7295
Curriculum Vitae
Education
Marquette University, 1973-1977
Milwaukee, Wisconsin
B.S. Medical Technology
Cardinal Stritch College, 1988-1990
Milwaukee, Wisconsin
M.S. Business Management
Medical College of Wisconsin, 1992-1994
Milwaukee, Wisconsin
Ph.D. Experimental Pathology
Employment/Professional
Medical College of Wisconsin, 1977-1987
Milwaukee, Wisconsin
Research Technologist, Microbial Pathogenesis
Medical College of Wisconsin, 1987-1990
Milwaukee, Wisconsin
Senior Research Technologist, Viral Pathogenesis
Medical College of Wisconsin, 1990-1992
Milwaukee, Wisconsin
Clinical Laboratory Coordinator, Special Viral Diagnostic Laboratory
Medical College of Wisconsin, 1994-1995
Milwaukee, Wisconsin
Senior Research Scientist, Department of Pathology
St. Luke's Medical Center, 1995-1997
Milwaukee, Wisconsin
Senior Research Associate, Immunotherapy Research and Treatment Institute
Accreditation
Board Certified, Medical Technology, American Society of Clinical
Pathologists
Memberships Professional Organizations
American Society for Microbiology
Consultant Position
HHV-6 Diagnostics
PelFreez Incorporated
Milwaukee, Wisconsin
January 1994 - December 1996
Awards
Travel Awards
Friends of the Medical College of Wisconsin
1993, 1994
1995 Distinguished Alumna
Program in Medical Laboratory Technology
Marquette University
Outstanding Doctoral Dissertation Award
Friends of the Medical College of Wisconsin
May, 1995
Travel Award
20th International Herpesvirus Workshop
Groningen; The Netherlands
August, 1995
Peer Reviewer
Blood
Trends in Microbiology
The Wellcome Trust; London, United Kingdom
Clinical Infectious Diseases
Journal of Infectious Diseases
Patents
Title: Human Virus Associated with Chronic Fatigue Immune Deficiency
Syndrome and Assay Therefore
Inventors: Grossberg SE, Kushnaryov VM, Cashdollar LW, Carrigan DR and Knox KK
Number: 5,827,750
Status: Granted on October 27, 1998
Title: Rapid Method for Diagnosis of Human Herpesvirus 6 Inventors: Knox KK
and Carrigan DR
Number: 60/079,379
Filing Date: March 26, 1998
Status: Pending
Past and Current Research Support
Co-Principal Investigator
Project Title: Role of HHV-6 in AIDS
Cancer Center of the Medical College of Wisconsin
Period of Support: 7/1/95-6/30/96
Annual Direct Cost: $10,000
Principal Investigator
Project Title: Human Herpesvirus Six Associated Bone Marrow Suppression in
Bone Marrow Transplant Patients
The Lauri Strauss Leukemia Foundation
Period of Support: 1/1/96-12/31/96
Annual Direct Cost: $25,000
Co-Principal Investigator
Project Title: HHV-6 in Multiple Sclerosis
National Multiple Sclerosis Society
New York, New York
Period of Support: 3/1/97-2/28/98
Direct Cost: $25,000
Principal Investigator
Project Title: Role of HHV-6A in the Chronic Fatigue Syndrome
Research Grant
The CFIDS Association of America, Inc.
Period of Support: 6/1/97 - 5/31/98
Annual Direct Cost: $84,500
Co-Principal Investigator
Project Title: Prospective Study of HHV-6 Infections in Liver Transplant
Recipients
Thomas E. Starzl Transplantation Institute
Period of Support: 1/1/98 - 6/30/98
Annual Direct Cost: $20,000
Co-Principal Investigator
Project Title: Prospective Study of HHV-6 in Multiple Sclerosis
Research Grant
National MS Society
Period of Support: 6/1/98-5/30/99
Annual Direct Cost: $25,000
Co-Principal Investigator
Project Title: In Vitro Screening of Compounds for Ability to Suppress the
Replication of Human Herpesvirus Six: Special Reference to Chronic Fatigue
Syndrome
The CFIDS Association of America
Period of Support: 4/1/99 - 3/31/00
Annual Direct Cost: $29,500
Teaching Experience
Instructor, Medical Pathology Course
Medical College of Wisconsin
Fall, 1994
Recent Invited Lectureships
"Active Infection of CNS Tissues, Peripheral Blood Leukocytes and
Lymphoid Tissues with Human Herpesvirus Six in Patients with Multiple
Sclerosis"
24th International Herpesvirus Workshop
Boston, Massachusetts
July 17, 1999
"Candidate Agents in MS: HHV-6"
Symposium on Demonstrating Infectious Cause: Viral and Bacterial Infections in
MS and Related Disorders
Sponsored by The National Multiple Sclerosis Society
Brighton, England
August 23-25, 1999
"Herpesviruses and Multiple Sclerosis"
European Charcot Foundation Symposium 1999
Venice, Italy
October 28-30, 1999
"Human Herpesvirus Six Infection After Autologous Stem Cell
Transplantation"
International Bone Marrow Transplant and American Society for Blood and Marrow
Transplantation Meeting
Anaheim, California
March 28, 2000
Selected Articles in Peer Reviewed Journals (from a total of 33):
1. Knox KK, Pietryga D, Franciosi R, and Carrigan DR. (1995). Progressive
immunodeficiency and fatal pneumonitis associated with HHV-6 infection in an
infant. Clin Infect Dis 20:406-413.
2. Knox KK, Harrington D and Carrigan DR. (1995). Fulminant human
herpesvirus six (HHV-6) encephalitis in an HIV infected infant. J Med Virol
45:288-292.
3. Knox KK and Carrigan DR. (1995). Active human herpesvirus six (HHV-6)
infection of the central nervous system in patients with AIDS. J Acquired
Immune Defic Syndromes, 9:69-73.
4. Carrigan DR and Knox KK. (1995). Bone marrow suppression by human
herpesvirus six (HHV-6): Comparison of the A and B variants of the virus.
Blood, 86:835-836.
5. Rosenfeld CS, Weinbaum D, Carrigan DR, Knox KK, Andrews DF, and Shadduck
RK. (1995). Late graft failure due to dual bone marrow infection with variants
A and B of human herpesvirus 6. Exper Hematology, 23:626-629.
6. Knox KK and Carrigan DR. (1996). Chronic marrow suppression in a bone
marrow transplant patient associated with persistent HHV-6 marrow infection.
Clin Infect Dis, 22:174-175.
7. Knox KK, Carrigan DR. (1996). Active HHV-6 infections in the lymph nodes
of HIV infected patients: In vitro evidence that HHV-6 can break HIV latency.
J Acquired Immune Defic Syndr and Hum Retrovirol, 11:370-378.
8. Carrigan DR, Harrington D and Knox KK. (1996). Subacute
leukoencephalitis caused by CNS infection with human herpesvirus six
manifesting as acute multiple sclerosis. Neurology, 45:145-150.
9. Carrigan DR, Harrington D and Knox KK. (1996). Variant A human
herpesvirus six as a cofactor in the pathogenesis of AIDS. J Acquired Immune
Defic Syndr and Hum Retrovirol, 13:97-98.
10. Carrigan DR and Knox KK. (1999). Pathogenic role of human herpesvirus 6
in transplantation. Curr Opin Organ Transplant, 4:285-291.
11. Rogers J, Singh N, Carrigan DR, Rohal S, Kusne S, Knox KK, Wagener MM
and Fung JJ. (2000). Prospective study of direct and indirect sequelae of
human herpesvirus 6 infection in liver transplant recipients. Transplantation,
in press.
11. Knox KK, Brewer JH, Harrington DJ, Henry JM, and Carrigan DR. (2000).
Active infection of CNS tissues, peripheral blood leukocytes and lymphoid
tissues with human herpesvirus six in patients with multiple sclerosis. Clin
Infect Dis, submitted for publication.
Selected Abstracts for Presentations at National and International Meetings
1. Carrigan DR and Knox KK. Active human herpesvirus six (HHV-6) infection
of the CNS in patients with AIDS. Second National Conference on Human
Retroviruses and Related Infections, 1995, Washington, D.C.
2. Knox KK and Carrigan DR. In vitro studies of HHV-6 and HIV on low
density bone marrow mononuclear cells. International Conference on Human
Herpesviruses 6 and 7, 1995; Atlanta, Georgia.
3. Knox KK and Carrigan DR. Frequent HHV-6 infection of the bone marrows of
patients with AIDS: Evidence for TNF-a induction and enhancement of HIV
replication. 20th International Herpesvirus Workshop, 1995; Gronigen, The
Netherlands.
4. Carrigan D, Milburn G, Dienglewicz R, Kernan N, Papadopoulos E, Knox K
and Singh N. Diagnosis of active human herpesvirus six (HHV-6) infections in
immunocompromised patients with a rapid shell-vial assay. American Society for
Microbiology 1996. San Francisco, California.
5. Knox KK and Carrigan DR. Human herpesvirus six and demyelinating
diseases of the central nervous system. 1996 Institute of Human Virology
Annual Meeting. University of Maryland Biotechnology Institute. Baltimore,
Maryland. September, 1996.
6. Knox KK and Carrigan DR. Histopathological correlates of HHV-6
infections in the lymph nodes of HIV-1 infected individuals. 1996 Institute of
Human Virology Annual Meeting. University of Maryland Biotechnology Institute.
Baltimore, Maryland. September, 1996.
7. Knox KK, Harrington D and Carrigan DR. Variable Sensitivities of Human
Herpesvirus Six Strains to Inhibition by Acyclovir. Second International
Conference on Human Herpesviruses 6, 7 and 8. Pisa, Italy. May, 1997.
8. Knox KK, Harrington D and Carrigan DR. Human Herpesvirus Six and
Demyelinating Diseases of the Central Nervous System. Second International
Conference on Human Herpesviruses 6, 7 and 8. Pisa, Italy. May, 1997.
9. Knox KK and Carrigan DR. Histopathological Correlates of HHV-6A
Infections in the Lymph Nodes of HIV-1 Infected Individuals. Second
International Conference on Human Herpesviruses 6, 7 and 8. Pisa, Italy. May,
1997.
10. Knox KK and Carrigan DR. Active HHV-6 Infections in Patients with
Chronic Fatigue Syndrome. Second International Conference on Human
Herpesviruses 6, 7 and 8. Pisa, Italy. May, 1997.
11. Knox KK and Carrigan DR. Human Herpesvirus Six Associated Diseases of
the Central Nervous System. 37th Interscience Conference on Antimicrobial
Agents and Chemotherapy, 1997.
12. Knox KK, Brewer JH, Harrington D and Carrigan DR. Active Human
Herpesvirus Six Infections Are Present in the CNS, Lymphoid Tissues and
Peripheral Blood of Patients with Multiple Sclerosis. 38th Interscience
Conference on Antimicrobial Agents and Chemotherapy, 1998.
13. Knox KK, Brewer JH and Carrigan DR. Multiple Sclerosis (MS) Patients
Have Active Human Herpesvirus Six (HHV-6) Infections in their CNS, Lymphoid
Tissues and Peripheral Blood. 36th Annual Meeting of Infectious Disease
Society of America, 1998.
14. Knox KK, JH Brewer and DR Carrigan. Persistent Active Human Herpesvirus
Six Infections in Patients with Chronic Fatigue Syndrome. Fourth International
American Association for Chronic Fatigue Syndrome Conference, 1998
15. Rogers J, Rohal S, Kusne S, Knox KK, Carrigan DR, Wagener MM, Fung JJ
and Singh N. Human Herpesvirus 6 (HHV-6) Viremia is an Independent Predictor
of Invasive Fungal Infections in Liver Transplant Recipients. 39th
Interscience Conference on Antimicrobial Agents and Chemotherapy, 1999.
16. Belko J, Burchett S, Knox KK and Carrigan DR. Fulminant Hepatitis in an
Immunocompetent Child Associated with Active HHV-6 Variant A (HHV-6A)
Infection. 39th Interscience Conference on Antimicrobial Agents and
Chemotherapy, 1999.
17. Brewer JH, Knox KK and Carrigan DR. Human Herpesvirus Six (HHV-6) and
Multiple Sclerosis: Active Infections are Preferentially Present in the Blood
of Patients with Early Disease. 39th Interscience Conference on Antimicrobial
Agents and Chemotherapy, 1999.
18. Knox KK and Carrigan DR. Human Herpesvirus Six (HHV-6) and Multiple
Sclerosis: Potential Role as Trigger of the Disease Process. New York Academy
of Sciences; New York, New York. October, 1999.
19. Brewer JH, Knox KK and Carrigan DR. Longitudinal Study of Chronic
Active Human Herpesvirus 6 (HHV-6) Viremia in Patients with Chronic Fatigue
Syndrome. 37th Annual Meeting of the Infectious Diseases Society of America,
1999.
20. Brewer JH, Knox KK and Carrigan DR. Severe Dysfunction of Natural
Killer (NK) Cells Associated with Chronic Active Human Herpesvirus 6 (HHV-6)
Viremia in Patients with Chronic Fatigue Syndrome. 37th Annual Meeting of the
Infectious Diseases Society of America, 1999.
21. Achilleos AN, Lister J, Zeigler Z, Raymond JM, Knox KK, Carrigan DR,
and Shadduck RK. Human Herpesvirus 6 (HHV-6) Infection After Hematopoietic
Stem Cell Transplantation (HSCT). 41st Annual Meeting of the American Society
of Hematology, 1999.
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