Wisconsin Viral Research Group, Ltd. Konstance K. Knox, Ph.D.

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Konstance K. Knox, Ph.D.

President and Director of Research
Wisconsin Viral Research Group, Ltd
10437 Innovation Drive, Suite 321
Milwaukee, Wisconsin 53226
Telephone: (414) 774-8612
Fax: (414) 453-7295

Curriculum Vitae

Education

Marquette University, 1973-1977
Milwaukee, Wisconsin
B.S. Medical Technology

Cardinal Stritch College, 1988-1990
Milwaukee, Wisconsin
M.S. Business Management

Medical College of Wisconsin, 1992-1994
Milwaukee, Wisconsin
Ph.D. Experimental Pathology

Employment/Professional

Medical College of Wisconsin, 1977-1987
Milwaukee, Wisconsin
Research Technologist, Microbial Pathogenesis

Medical College of Wisconsin, 1987-1990
Milwaukee, Wisconsin
Senior Research Technologist, Viral Pathogenesis

Medical College of Wisconsin, 1990-1992
Milwaukee, Wisconsin
Clinical Laboratory Coordinator, Special Viral Diagnostic Laboratory

Medical College of Wisconsin, 1994-1995
Milwaukee, Wisconsin
Senior Research Scientist, Department of Pathology

St. Luke's Medical Center, 1995-1997
Milwaukee, Wisconsin
Senior Research Associate, Immunotherapy Research and Treatment Institute

 

Accreditation

Board Certified, Medical Technology, American Society of Clinical Pathologists

Memberships Professional Organizations

American Society for Microbiology

 

Consultant Position

HHV-6 Diagnostics
PelFreez Incorporated
Milwaukee, Wisconsin
January 1994 - December 1996

Awards

Travel Awards
Friends of the Medical College of Wisconsin
1993, 1994

1995 Distinguished Alumna
Program in Medical Laboratory Technology
Marquette University

Outstanding Doctoral Dissertation Award
Friends of the Medical College of Wisconsin
May, 1995

Travel Award
20th International Herpesvirus Workshop
Groningen; The Netherlands
August, 1995

Peer Reviewer

Blood
Trends in Microbiology
The Wellcome Trust; London, United Kingdom
Clinical Infectious Diseases
Journal of Infectious Diseases

Patents

Title: Human Virus Associated with Chronic Fatigue Immune Deficiency Syndrome and Assay Therefore
Inventors: Grossberg SE, Kushnaryov VM, Cashdollar LW, Carrigan DR and Knox KK
Number: 5,827,750
Status: Granted on October 27, 1998

Title: Rapid Method for Diagnosis of Human Herpesvirus 6 Inventors: Knox KK and Carrigan DR
Number: 60/079,379
Filing Date: March 26, 1998
Status: Pending

Past and Current Research Support

Co-Principal Investigator
Project Title: Role of HHV-6 in AIDS
Cancer Center of the Medical College of Wisconsin
Period of Support: 7/1/95-6/30/96
Annual Direct Cost: $10,000

Principal Investigator
Project Title: Human Herpesvirus Six Associated Bone Marrow Suppression in Bone Marrow Transplant Patients
The Lauri Strauss Leukemia Foundation
Period of Support: 1/1/96-12/31/96
Annual Direct Cost: $25,000

Co-Principal Investigator
Project Title: HHV-6 in Multiple Sclerosis
National Multiple Sclerosis Society
New York, New York
Period of Support: 3/1/97-2/28/98
Direct Cost: $25,000

Principal Investigator
Project Title: Role of HHV-6A in the Chronic Fatigue Syndrome
Research Grant
The CFIDS Association of America, Inc.
Period of Support: 6/1/97 - 5/31/98
Annual Direct Cost: $84,500

Co-Principal Investigator
Project Title: Prospective Study of HHV-6 Infections in Liver Transplant Recipients
Thomas E. Starzl Transplantation Institute
Period of Support: 1/1/98 - 6/30/98
Annual Direct Cost: $20,000

Co-Principal Investigator
Project Title: Prospective Study of HHV-6 in Multiple Sclerosis
Research Grant
National MS Society
Period of Support: 6/1/98-5/30/99
Annual Direct Cost: $25,000

Co-Principal Investigator
Project Title: In Vitro Screening of Compounds for Ability to Suppress the Replication of Human Herpesvirus Six: Special Reference to Chronic Fatigue Syndrome
The CFIDS Association of America
Period of Support: 4/1/99 - 3/31/00
Annual Direct Cost: $29,500

Teaching Experience

Instructor, Medical Pathology Course
Medical College of Wisconsin
Fall, 1994

Recent Invited Lectureships

"Active Infection of CNS Tissues, Peripheral Blood Leukocytes and Lymphoid Tissues with Human Herpesvirus Six in Patients with Multiple Sclerosis"
24th International Herpesvirus Workshop
Boston, Massachusetts
July 17, 1999

"Candidate Agents in MS: HHV-6"
Symposium on Demonstrating Infectious Cause: Viral and Bacterial Infections in MS and Related Disorders
Sponsored by The National Multiple Sclerosis Society
Brighton, England
August 23-25, 1999

"Herpesviruses and Multiple Sclerosis"
European Charcot Foundation Symposium 1999
Venice, Italy
October 28-30, 1999

"Human Herpesvirus Six Infection After Autologous Stem Cell Transplantation"
International Bone Marrow Transplant and American Society for Blood and Marrow Transplantation Meeting
Anaheim, California
March 28, 2000

Selected Articles in Peer Reviewed Journals (from a total of 33):

1. Knox KK, Pietryga D, Franciosi R, and Carrigan DR. (1995). Progressive immunodeficiency and fatal pneumonitis associated with HHV-6 infection in an infant. Clin Infect Dis 20:406-413.

2. Knox KK, Harrington D and Carrigan DR. (1995). Fulminant human herpesvirus six (HHV-6) encephalitis in an HIV infected infant. J Med Virol 45:288-292.

3. Knox KK and Carrigan DR. (1995). Active human herpesvirus six (HHV-6) infection of the central nervous system in patients with AIDS. J Acquired Immune Defic Syndromes, 9:69-73.

4. Carrigan DR and Knox KK. (1995). Bone marrow suppression by human herpesvirus six (HHV-6): Comparison of the A and B variants of the virus. Blood, 86:835-836.

5. Rosenfeld CS, Weinbaum D, Carrigan DR, Knox KK, Andrews DF, and Shadduck RK. (1995). Late graft failure due to dual bone marrow infection with variants A and B of human herpesvirus 6. Exper Hematology, 23:626-629.

6. Knox KK and Carrigan DR. (1996). Chronic marrow suppression in a bone marrow transplant patient associated with persistent HHV-6 marrow infection. Clin Infect Dis, 22:174-175.

7. Knox KK, Carrigan DR. (1996). Active HHV-6 infections in the lymph nodes of HIV infected patients: In vitro evidence that HHV-6 can break HIV latency. J Acquired Immune Defic Syndr and Hum Retrovirol, 11:370-378.

8. Carrigan DR, Harrington D and Knox KK. (1996). Subacute leukoencephalitis caused by CNS infection with human herpesvirus six manifesting as acute multiple sclerosis. Neurology, 45:145-150.

9. Carrigan DR, Harrington D and Knox KK. (1996). Variant A human herpesvirus six as a cofactor in the pathogenesis of AIDS. J Acquired Immune Defic Syndr and Hum Retrovirol, 13:97-98.

10. Carrigan DR and Knox KK. (1999). Pathogenic role of human herpesvirus 6 in transplantation. Curr Opin Organ Transplant, 4:285-291.

11. Rogers J, Singh N, Carrigan DR, Rohal S, Kusne S, Knox KK, Wagener MM and Fung JJ. (2000). Prospective study of direct and indirect sequelae of human herpesvirus 6 infection in liver transplant recipients. Transplantation, in press.

11. Knox KK, Brewer JH, Harrington DJ, Henry JM, and Carrigan DR. (2000). Active infection of CNS tissues, peripheral blood leukocytes and lymphoid tissues with human herpesvirus six in patients with multiple sclerosis. Clin Infect Dis, submitted for publication.

Selected Abstracts for Presentations at National and International Meetings

1. Carrigan DR and Knox KK. Active human herpesvirus six (HHV-6) infection of the CNS in patients with AIDS. Second National Conference on Human Retroviruses and Related Infections, 1995, Washington, D.C.

2. Knox KK and Carrigan DR. In vitro studies of HHV-6 and HIV on low density bone marrow mononuclear cells. International Conference on Human Herpesviruses 6 and 7, 1995; Atlanta, Georgia.

3. Knox KK and Carrigan DR. Frequent HHV-6 infection of the bone marrows of patients with AIDS: Evidence for TNF-a induction and enhancement of HIV replication. 20th International Herpesvirus Workshop, 1995; Gronigen, The Netherlands.

4. Carrigan D, Milburn G, Dienglewicz R, Kernan N, Papadopoulos E, Knox K and Singh N. Diagnosis of active human herpesvirus six (HHV-6) infections in immunocompromised patients with a rapid shell-vial assay. American Society for Microbiology 1996. San Francisco, California.

5. Knox KK and Carrigan DR. Human herpesvirus six and demyelinating diseases of the central nervous system. 1996 Institute of Human Virology Annual Meeting. University of Maryland Biotechnology Institute. Baltimore, Maryland. September, 1996.

6. Knox KK and Carrigan DR. Histopathological correlates of HHV-6 infections in the lymph nodes of HIV-1 infected individuals. 1996 Institute of Human Virology Annual Meeting. University of Maryland Biotechnology Institute. Baltimore, Maryland. September, 1996.

7. Knox KK, Harrington D and Carrigan DR. Variable Sensitivities of Human Herpesvirus Six Strains to Inhibition by Acyclovir. Second International Conference on Human Herpesviruses 6, 7 and 8. Pisa, Italy. May, 1997.

8. Knox KK, Harrington D and Carrigan DR. Human Herpesvirus Six and Demyelinating Diseases of the Central Nervous System. Second International Conference on Human Herpesviruses 6, 7 and 8. Pisa, Italy. May, 1997.

9. Knox KK and Carrigan DR. Histopathological Correlates of HHV-6A Infections in the Lymph Nodes of HIV-1 Infected Individuals. Second International Conference on Human Herpesviruses 6, 7 and 8. Pisa, Italy. May, 1997.

10. Knox KK and Carrigan DR. Active HHV-6 Infections in Patients with Chronic Fatigue Syndrome. Second International Conference on Human Herpesviruses 6, 7 and 8. Pisa, Italy. May, 1997.

11. Knox KK and Carrigan DR. Human Herpesvirus Six Associated Diseases of the Central Nervous System. 37th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1997.

12. Knox KK, Brewer JH, Harrington D and Carrigan DR. Active Human Herpesvirus Six Infections Are Present in the CNS, Lymphoid Tissues and Peripheral Blood of Patients with Multiple Sclerosis. 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1998.

13. Knox KK, Brewer JH and Carrigan DR. Multiple Sclerosis (MS) Patients Have Active Human Herpesvirus Six (HHV-6) Infections in their CNS, Lymphoid Tissues and Peripheral Blood. 36th Annual Meeting of Infectious Disease Society of America, 1998.

14. Knox KK, JH Brewer and DR Carrigan. Persistent Active Human Herpesvirus Six Infections in Patients with Chronic Fatigue Syndrome. Fourth International American Association for Chronic Fatigue Syndrome Conference, 1998

15. Rogers J, Rohal S, Kusne S, Knox KK, Carrigan DR, Wagener MM, Fung JJ and Singh N. Human Herpesvirus 6 (HHV-6) Viremia is an Independent Predictor of Invasive Fungal Infections in Liver Transplant Recipients. 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1999.

16. Belko J, Burchett S, Knox KK and Carrigan DR. Fulminant Hepatitis in an Immunocompetent Child Associated with Active HHV-6 Variant A (HHV-6A) Infection. 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1999.

17. Brewer JH, Knox KK and Carrigan DR. Human Herpesvirus Six (HHV-6) and Multiple Sclerosis: Active Infections are Preferentially Present in the Blood of Patients with Early Disease. 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1999.

18. Knox KK and Carrigan DR. Human Herpesvirus Six (HHV-6) and Multiple Sclerosis: Potential Role as Trigger of the Disease Process. New York Academy of Sciences; New York, New York. October, 1999.

19. Brewer JH, Knox KK and Carrigan DR. Longitudinal Study of Chronic Active Human Herpesvirus 6 (HHV-6) Viremia in Patients with Chronic Fatigue Syndrome. 37th Annual Meeting of the Infectious Diseases Society of America, 1999.

20. Brewer JH, Knox KK and Carrigan DR. Severe Dysfunction of Natural Killer (NK) Cells Associated with Chronic Active Human Herpesvirus 6 (HHV-6) Viremia in Patients with Chronic Fatigue Syndrome. 37th Annual Meeting of the Infectious Diseases Society of America, 1999.

21. Achilleos AN, Lister J, Zeigler Z, Raymond JM, Knox KK, Carrigan DR, and Shadduck RK. Human Herpesvirus 6 (HHV-6) Infection After Hematopoietic Stem Cell Transplantation (HSCT). 41st Annual Meeting of the American Society of Hematology, 1999.

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